Oxidation of  l ‐Methionine by Bisperoxo(1,10‐phenanthroline)oxovanadate(V): A Mechanistic Study | Zendy

Chakrabarty Sanchita | Zendy; Banerjee Rupendranath | Zendy

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Oxidation of l ‐Methionine by Bisperoxo(1,10‐phenanthroline)oxovanadate(V): A Mechanistic Study

Author(s) -

Chakrabarty Sanchita,

Banerjee Rupendranath

Publication year - 2016

Publication title -

international journal of chemical kinetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.341

H-Index - 68

eISSN - 1097-4601

pISSN - 0538-8066

DOI - 10.1002/kin.20990

Subject(s) - chemistry , methionine , phenanthroline , methionine sulfoxide , stoichiometry , reaction rate constant , medicinal chemistry , phosphate buffered saline , electron paramagnetic resonance , kinetics , stereochemistry , organic chemistry , biochemistry , amino acid , chromatography , physics , quantum mechanics , nuclear magnetic resonance

In phosphate buffer media (pH 5.8–8.0), bisperoxo(1,10‐phenanthroline)oxovanadate(V) ( 1 ) oxidizes l ‐methionine to methionine sulfoxide. The stoichiometry of the reaction is 1:1. The reaction occurs in two subsequent first‐order steps. In the first step, one of the peroxo ligands of 1 gets substituted by l ‐methionine. The observed first‐order rate constants for both steps increase linearly with increasing [H + ] as well as with increasing [ l ‐methionine]. The EPR spectra prove that the reaction involves a cysteinyl radical‐type intermediate and that V V gets reduced to a V IV species.

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