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Bromination of Anisoles Using N‐Bromophthalimide: A Synthetic and Kinetic Approach
Author(s) -
Anjaiah B.,
Kumar M. Satish,
Srinivas P.,
Rajanna K. C.
Publication year - 2016
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.20974
Subject(s) - anisole , chemistry , halogenation , acetic acid , derivative (finance) , kinetics , kinetic energy , organic chemistry , aqueous solution , medicinal chemistry , catalysis , physics , quantum mechanics , financial economics , economics
N‐Bromophthalimide (NBP)‐triggered bromination of aromatic compounds has been studied in the presence of aqueous acetic acid. Reaction Kinetics indicated first order in [NBP] and zero order in [Anisole]. The reactions afforded very good yields of corresponding bromo derivatives under kinetic conditions. The mechanism of the reaction is explained through the formation of acetyl hypobromite due to the interaction of NBP and acetic acid, which in turn reacts with anisole to afford a bromo derivative of anisole.