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Reactivity of Dinuclear Copper(II) Complexes with N ‐Salicylidene Glycine Schiff Bases as Carboxylesterase Models
Author(s) -
Xu Bin,
Jiang Weidong,
Liu Fuan,
Yu Yongde,
Dong Juan
Publication year - 2015
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.20904
Subject(s) - chemistry , schiff base , copper , hydrolysis , glycine , reactivity (psychology) , medicinal chemistry , chloride , kinetic energy , polymer chemistry , inorganic chemistry , stereochemistry , organic chemistry , amino acid , biochemistry , medicine , physics , quantum mechanics , alternative medicine , pathology
Two phenoxo‐bridged dinuclear copper(II) complexes (Cu 2 L 1 2 , Cu 2 L 2 2 ) with N ‐salicylidene glycine Schiff bases were prepared and evaluated their performance for catalyzing the hydrolysis of p ‐nitrophenyl picolinate (PNPP). The observations reveal that the as‐prepared dinuclear copper(II) complexes exhibited better activity by two to three orders of magnitude rate enhancement in comparison with the autohydrolysis rate of PNPP. Chloro‐containing Cu 2 L 2 2 aroused approximately three times kinetic advantage over chloro‐free Cu 2 L 1 2 at pH 7.0, which is probably contributed to the electron‐withdrawing inductive effect of the 5 ′ ‐chloride group. Moreover, it was found that the pH‐responded kinetic behavior displayed an enzyme‐like property for the PNPP hydrolysis by the two complexes.