Premium
Kinetics of Hydrolysis of Bisoprolol Hemifumarate in Aqueous Acidic Solutions
Author(s) -
Szalka Mateusz,
Rokaszewski Edward,
Kaczmarski Krzysztof
Publication year - 2013
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.20809
Subject(s) - chemistry , kinetics , enthalpy , hydrolysis , activation energy , reaction rate constant , aqueous solution , entropy of activation , entropy (arrow of time) , order of reaction , inorganic chemistry , chromatography , thermodynamics , organic chemistry , physics , quantum mechanics
The kinetics of hydrolysis of bisoprolol hemifumarate in acidic conditions was studied using high‐performance liquid chromatography. For this purpose, different hydrohalic acids and one weak carboxylic acid were used. The rate constants, the order of the reaction, and the activation parameters: enthalpy, entropy, and energy of activation were calculated. A proposition for the mechanism of degradation was provided.