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Kinetic and thermodynamic analysis of degradation of doripenem in the solid state
Author(s) -
CieleckaPiontek Judyta,
JelińSka Anna,
Dołhań Agnieszka,
Zalewski Przemysław
Publication year - 2012
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.20722
Subject(s) - doripenem , chemistry , kinetic energy , degradation (telecommunications) , thermodynamics , relative humidity , kinetics , autocatalysis , analytical chemistry (journal) , chromatography , organic chemistry , catalysis , biochemistry , telecommunications , physics , antibiotic resistance , imipenem , quantum mechanics , computer science , antibiotics
Abstract The kinetic and thermodynamic parameters of degradation of doripenem were studied using a high‐performance liquid chromatography method. In dry air, the degradation of doripenem was a first‐order reaction depending on the substrate concentration. At increased relative air humidity, doripenem was degraded according to the autocatalysis kinetic model. The dependence ln k = f 1/ T ) was described by the equations ln k = 5.10 ± 13.06 − (7576 ± 4939)(1/ T ) in dry air and ln k = 46.70 ± 22.44 − (19,959 ± 8031)(1/ T ) at 76.4% relative humidity (RH). The thermodynamic parameters E a , Δ H ≠a , and Δ S ≠a of the degradation of doripenem were calculated. The dependence ln k = f (RH%) was described by the equation ln k = (0.155 ± 0.077) × 10 −1 (RH%) − (3.45 ± 21.8) × 10 −10 . © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 722–728, 2012