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Kinetic study of the interaction of three glycine‐containing dipeptides with diaquaethylenediamineplatinum(II) in aqueous medium
Author(s) -
Mallick Subhasis,
Mondal Subala,
Mandal Arup,
Bera Biplab K.,
Karmakar Parnajyoti,
Ghosh Alak K.
Publication year - 2011
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.20577
Subject(s) - chemistry , zwitterion , glycine , ligand (biochemistry) , substrate (aquarium) , chelation , valine , stereochemistry , kinetics , aqueous solution , medicinal chemistry , amino acid , inorganic chemistry , organic chemistry , molecule , biochemistry , oceanography , receptor , physics , quantum mechanics , geology
Abstract The kinetics of the interaction of three glycine‐containing dipeptides, namely, glycine‐L‐leucine (Gly‐Leu), glycine‐L‐isoleucine (Gly‐Ile), and glycine‐valine (Gly‐Val) with [Pt(en)(H 2 O) 2 ](ClO 4 ) 2 has been studied spectrophotometrically as a function of [substrate complex], [dipeptides] and temperature at a particular pH(4.0), where the substrate complex exists predominantly as the diaqua species and the dipeptides as a zwitterion. The substitution reaction shows two consecutive steps; the first is the ligand‐assisted anation and the second is the chelation step. The activation parameters for both the steps were evaluated using Eyring's equation. The low ΔH 1 ≠ and large negative value of ΔS 1 ≠ as well as ΔH 2 ≠ and ΔS 2 ≠ indicate an associative mode of activation for both the aqua ligand substitution processes. © 2011 Wiley Periodicals, Inc. Int J Chem Kinet 43: 498–506, 2011