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Calix[ n ]arenes mediated phase‐transfer catalytic synthesis of purine derivatives
Author(s) -
Sharma Pratibha,
Kumar Ashok,
Sahu Vinita,
Singh Jitendra
Publication year - 2009
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.20394
Subject(s) - chemistry , catalysis , kinetics , methanol , acetonitrile , phase (matter) , mass transfer , combinatorial chemistry , organic chemistry , chromatography , physics , quantum mechanics
A new route was designed to achieve the synthesis of purine derivatives under phase‐transfer catalysis conditions using calix[ n ]arenes TAC n A ( n = 4, 6, and 8) as phase‐transfer catalyst for the first time in this particular type of synthesis. The compounds were synthesized in excellent yields (70%–80%) and the structures were established on the basis of consistent IR, 1 H NMR, FAB‐Mass, and elemental analyses data. Their purity has been ascertained by chromatographic resolution using acetonitrile, methanol, and water (50:30:20, v/v) as eluenting system. Moreover, the kinetics of the reaction was studied and it was found to obey first‐order kinetics. Effect of various parameters, namely, temperature, amount of catalyst, stirring speed, and so on was also investigated. © 2008 Wiley Periodicals, Inc. Int J Chem Kinet 41: 265–274, 2009