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Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms
Author(s) -
Palmeri Mark L.,
Milkowski Andy,
Barr Richard,
Carson Paul,
Couade Mathieu,
Chen Jun,
Chen Shigao,
Dhyani Manish,
Ehman Richard,
Garra Brian,
Gee Albert,
Guenette Gilles,
Hah Zaegyoo,
Lynch Ted,
Macdonald Michael,
Managuli Ravi,
Miette Veronique,
Nightingale Kathryn R.,
Obuchowski Nancy,
Rouze Ned C.,
Morris D. Cody,
Fielding Shana,
Deng Yufeng,
Chan Derek,
Choudhury Kingshuk,
Yang Siyun,
Samir Anthony E.,
Shamdasani Vijay,
Urban Matthew,
Wear Keith,
Xie Hua,
Ozturk Arinc,
Qiang Bo,
Song Pengfei,
McAleavey Stephen,
Rosenzweig Stephen,
Wang Michael,
Okamura Yoko,
McLaughlin Glen,
Chen Yuling,
Napolitano David,
Carlson Lindsey,
Erpelding Todd,
Hall Timothy J.
Publication year - 2021
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.15609
Subject(s) - magnetic resonance elastography , viscoelasticity , elastography , elasticity (physics) , acoustic radiation force , ultrasound , materials science , magnetic resonance imaging , biomedical engineering , shear waves , acoustics , ultrasonic sensor , shear (geology) , nuclear magnetic resonance , optics , physics , radiology , medicine , composite material
Objectives To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms. Methods Two elastic phantoms, representing healthy through fibrotic liver, were measured with 5 different ultrasound platforms, and 3 viscoelastic phantoms, representing healthy through fibrotic liver tissue, were measured with 12 different ultrasound platforms. Measurements were performed with different systems at different sites, at 3 focal depths, and with different appraisers. The SWS bias across the systems was quantified as a function of the system, site, focal depth, and appraiser. A single MRE research system was also used to characterize these phantoms using discrete frequencies from 60 to 500 Hz. Results The SWS from different systems had mean difference 95% confidence intervals of ±0.145 m/s (±9.6%) across both elastic phantoms and ± 0.340 m/s (±15.3%) across the viscoelastic phantoms. The focal depth and appraiser were less significant sources of SWS variability than the system and site. Magnetic resonance elastography best matched the ultrasonic SWS in the viscoelastic phantoms using a 140 Hz source but had a − 0.27 ± 0.027‐m/s (−12.2% ± 1.2%) bias when using the clinically implemented 60‐Hz vibration source. Conclusions Shear wave speed reconstruction across different manufacturer systems is more consistent in elastic than viscoelastic phantoms, with a mean difference bias of < ±10% in all cases. Magnetic resonance elastographic measurements in the elastic and viscoelastic phantoms best match the ultrasound systems with a 140‐Hz excitation but have a significant negative bias operating at 60 Hz. This study establishes a foundation for meaningful comparison of SWS measurements made with different platforms.