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Diagnostic Accuracy Evaluation of Two‐Dimensional Shear Wave Elastography in the Differentiation Between Benign and Malignant Thyroid Nodules
Author(s) -
Filho Raimundo Holanda Carneiro,
Pereira Fernando Linhares,
Iared Wagner
Publication year - 2020
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.15271
Subject(s) - medicine , receiver operating characteristic , elastography , confidence interval , thyroid nodules , malignancy , cochrane library , thyroid , nuclear medicine , radiology , ultrasound , pathology
Objectives To evaluate two‐dimensional (2D) shear wave elastography (SWE) performance as an independent predictor of malignancy in the diagnostic differentiation of thyroid nodules (TNs), including subgroup analyses of different manufacturers and respective cutoffs points. Methods The online databases MEDLINE (PubMed), Embase, and the Cochrane Library were searched for articles using 2D SWE in TN evaluation. After good‐quality relevant thyroid‐specific articles were selected, the main data, plus their sensitivity and specificity, were tabulated. Summary receiver operating characteristic curves were generated to verify the accuracy of data obtained from 3 manufactures. A meta‐analysis was performed to evaluate whether clinical recommendations can be improved by the use of 2D SWE to differentiate TNs. Results The sensitivity and specificity parameters of 2D SWE for the differentiation between benign and malignant TNs according to different instruments were, respectively, as follows: Toshiba SWE (Toshiba Medical Systems, Tochigi, Japan), 0.77 (95% confidence interval [CI], 0.70–0.83) and 0.76 (95% CI, 0.72–0.81); Virtual Touch tissue imaging and quantification (Siemens Medical Solutions, Mountain View, CA), 0.72 (95% CI, 0.67–0.77) and 0.81 (95% CI, 0.78–0.84); and SuperSonic SWE (SuperSonic Imagine, Aix‐en‐Provence, France), 0.63 (95% CI, 0.59–0.66) and 0.81 (95% CI, 0.79–0.83). The summary receiver operating characteristic curves showed the following area under the curve syntheses: Toshiba SWE, 0.84 ( Q * = 0.7707); Virtual Touch tissue imaging and quantification, 0.85 ( Q * = 0.7809); and SuperSonic SWE, 0.88 ( Q * = 0.8102). Positive and negative predictive values varied, respectively, from 16% to 94% and 29% to 100%, considering all included articles. The overall accuracy ranged from 53% to 93%. Conclusions Two‐dimensional SWE is a relevant and an important tool that supports ultrasound in clinical practice in the diagnostic differentiation between benign and malignant TNs.