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Complications After Percutaneous Ultrasound‐Guided Liver Biopsy
Author(s) -
Tian Guo,
Kong Dexing,
Jiang Tian'an,
Li Lanjuan
Publication year - 2020
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.15229
Subject(s) - medicine , complication , biopsy , percutaneous , confidence interval , radiology , surgery , fine needle aspiration , ultrasound
Objectives Percutaneous liver biopsy (LB) has been considered the reference standard in distinguishing the degree of liver disease, but there has been no definitive systematic review to assess complication rates or potential risk factors for them. Methods In this study, we searched the PubMed, Embase, Web of Science, and Scopus databases for studies appraising complication rates after percutaneous ultrasound (US)‐guided LB published until October 11, 2018. The safety and efficacy of US‐guided LB were estimated according to major and minor complications. Subgroups including the biopsy style, needle styles, mean number of needle insertions, study period, and specific complication items were analyzed. Results Among 12,481 patients from 51 studies, pooled results showed a low rate (0; 95% confidence interval, 0–0) of major and minor complications. The subgroup analysis indicated that US‐guided LB had a low major complication rate of 0 (0–0) for both fine‐needle aspiration and core biopsy, with rates of 0.016 (0–0.032) for 14‐gauge, 0.010 (0.003–0.017) for 15‐gauge, 0.002 (–0.001–0.005) for 20‐gauge, and 0 (0–0) for 16‐, 17‐, 18‐, 21‐, and 22‐gauge needles, and low minor complication rates of 0 (0–0) for fine‐needle aspiration and 0.001 (0–0.002) for core biopsy, with rates of 0.164 (0.137–0.191) for 15‐gauge, 0.316 (0.113–0.519) for 16‐gauge, and 0 (0–0) for 14‐, 17‐, 18‐, 20‐, 21‐, and 22‐gauge needles. Furthermore, specific complication rates of bleeding, pain, pneumothorax, vasovagal reactions, and death were all 0 (0–0). Conclusions These findings suggest that it is possible to safely perform percutaneous US‐guided LB.