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Association Between Shear Wave Elastography of Virtual Touch Tissue Imaging Quantification Parameters and the Ki‐67 Proliferation Status in Luminal‐Type Breast Cancer
Author(s) -
Liu Yubo,
Huang Yini,
Han Jing,
Wang Jianwei,
Li Fei,
Zhou Jianhua
Publication year - 2019
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14663
Subject(s) - medicine , receiver operating characteristic , lymphovascular invasion , breast cancer , confidence interval , hazard ratio , nuclear medicine , univariate analysis , elastography , lymph node , pathology , radiology , urology , cancer , ultrasound , multivariate analysis , metastasis
Objectives To evaluate the association between shear wave elastography parameters using virtual touch tissue imaging quantification (VTIQ) and the Ki‐67 index in luminal‐type breast cancer. Methods Eighty‐one patients with 82 lesions of pathologic confirmed luminal‐type breast cancer underwent virtual touch tissue imaging quantification examination before surgery between December 2015 and June 2016. Patients were divided into 2 groups according to the Ki‐67 index (≥14% versus < 14%), which is used to define luminal type B and luminal type A, respectively. The mean shear wave velocity (SWV mean ) and lesion‐to‐adjacent tissues ratio (SWV ratio) were calculated for each lesion. Results The SWV mean , SWV ratio, histologic grade, axillary lymph node involvement, and lymphovascular invasion showed a significant positive association with a high Ki‐67 index (all P < .05). Receiver operating characteristic curve analysis for the differential diagnosis between high (≥14%) and low (<14%) Ki‐67 groups displayed that the optimal cutoff value for SWV mean and SWV ratio were 3.99 meters per second and 2.861, with sensitivity 94% and 72%, specificity 40.6% and 56.2%, and area under the receiver operating characteristic curve of 0.689 and 0.651, respectively. Univariate analysis showed that SWV mean ( P = .005), SWV ratio ( P = .029), histologic grade ( P = .011), presence of axillary node involvement ( P = .004), and lymphovascular invasion ( P = .008) were significantly associated with high Ki‐67 status. Multivariable analysis displayed that SWV mean (hazard ratio [HR], 1.459, 95% confidence interval [CI], 1.028–2.072; P = .035), histologic grade (HR, 4.105; 95% CI, 1.142–14.763; P = .031), and presence of axillary node involvement (HR, 3.75; 95% CI, 1.228–11.453; P = .020) maintained significance for predicting high Ki‐67 status. Conclusions The SWV mean using the virtual touch tissue imaging quantification method showed significant correlation with the Ki‐67 index, suggesting the potential to assess tumor proliferation status in luminal‐type breast cancer with a noninvasive manner.