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Clinical Usefulness of the Microbubble Contrast Agent SonoVue in Enhancing the Effects of High‐Intensity Focused Ultrasound for the Treatment of Adenomyosis
Author(s) -
Jingqi Wang,
Lu Zhang,
Jun Zhang,
Yuhong Ma,
Wei Yang,
Lifeng Ran,
Chengbing Jin,
Dobromir Dimitrov Dimitrov,
Hui Zhu,
Kun Zhou
Publication year - 2018
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14638
Subject(s) - medicine , high intensity focused ultrasound , adenomyosis , ultrasound , ablation , magnetic resonance imaging , perioperative , nuclear medicine , radiology , urology , surgery , endometriosis
Objective To evaluate the clinical usefulness of the microbubble contrast agent SonoVue in enhancing high‐intensity focused ultrasound (HIFU) for the treatment of adenomyosis. Methods A total of 102 patients with adenomyosis, assessed from August 2015 to April 2017, were randomly divided into 1‐minute (A) and 10‐minute (B) groups, respectively. In groups A and B, HIFU started 1 minute and 10 minutes, respectively, after SonoVue injection. All patients underwent a magnetic resonance imaging scan before and after HIFU treatment. Results The occurrence rates of massive gray scale change, nonperfused volume, and fractional ablation were similar in both groups ( P > .05). Meanwhile, sonication time to massive gray scale change was reduced in group A compared with group B ( P < .05). In addition, mean power, total energy, and energy efficiency factor were lower in group A than group B (all P < .05). The incidence rates of most perioperative and all postoperative adverse events were similar in both groups ( P > .05). The incidence rates of pain in the treated region, leg pain, and sciatic or buttock pain during HIFU were substantially lower in group A than group B ( P < .05). Conclusions Overall, starting HIFU sonication at 1 minute after SonoVue injection enhances HIFU ablation by cavitation and heating and is safe. Early massive gray scale change, lower total energy, and reduced mean power are potential safety factors.