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A Yolk Sac Larger Than 5 mm Suggests an Abnormal Fetal Karyotype, Whereas an Absent Embryo Indicates a Normal Fetal Karyotype
Author(s) -
Yoneda Satoshi,
Shiozaki Arihiro,
Yoneda Noriko,
Sameshima Azusa,
Ito Mika,
Shima Tomoko,
Nakashima Akitoshi,
Yoshino Osamu,
Kigawa Mika,
Takamori Ryosuke,
Shinagawa Yasuhiro,
Saito Shigeru
Publication year - 2018
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14467
Subject(s) - karyotype , yolk sac , medicine , fetus , embryo , andrology , anatomy , pregnancy , chromosome , genetics , biology , gene
Objectives It is very hard to estimate an abnormal or normal fetal karyotype in miscarriage before surgery. We investigated whether the abnormal fetal karyotype in early miscarriage could be estimated by comprehensive ultrasonographic findings by a multivariate analysis. Methods One hundred fifty‐one patients with early miscarriage (<12 weeks' gestation) were selected in our hospital. The clinical characteristics were compared between pregnant women carrying a fetus with an abnormal karyotype and those with a normal one, and the size and configuration of the gestational sac, yolk sac, and embryo at diagnosis of early miscarriage were also evaluated. Results The rate of abnormal fetal karyotypes was 66.2 % (100 of 151). A maternal age older than 35 years (odds ratio, 3.2; 95% confidence interval, 1.4–7.4; P = .005), yolk sac larger than 5 mm (odds ratio, 6.2; 95% confidence interval, 2.2–22.7, P < .001), and absent embryo (odds ratio, 0.40; 95% confidence interval, 0.16–0.95; P = .038) were independent markers for predicting an abnormal fetal karyotype by multiple logistic regression analysis. Conclusions At the point of early miscarriage diagnosis, a yolk sac larger than 5 mm suggests an abnormal fetal karyotype, whereas an absent embryo indicates a normal fetal karyotype.