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Correlations Among Ultrasound‐Guided Diffuse Optical Tomography, Microvessel Density, and Breast Cancer Prognosis
Author(s) -
Niu Sihua,
Zhu Qingli,
Jiang Yuxin,
Zhu Jiaan,
Xiao Mengsu,
You Shanshan,
Zhou Weixun,
Xiao Yu
Publication year - 2018
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14416
Subject(s) - medicine , breast cancer , microvessel , metastasis , receiver operating characteristic , ultrasound , radiology , cancer , pathology , nuclear medicine , gastroenterology , immunohistochemistry
Objectives To investigate the correlation among ultrasound‐guided diffuse optical tomography (DOT), microvessel density, and breast cancer prognosis. Methods Before surgery, the total hemoglobin (Hb) concentrations of 184 female patients with breast cancer with only a single lesion were measured. During follow‐up, 23 patients had recurrence or metastatic disease after surgery. Among these patients, 18 with recurrence or metastatic disease within 3 years after surgery were paired with 18 patients without recurrence or metastatic disease. We retrospectively reviewed the pathologic sections of those 36 patients, conducted immunohistochemical staining, and counted the microvessel densities. Then we analyzed the correlation between microvessel density and total Hb, compared total Hb and microvessel density among breast cancers with different prognoses, and tested the value of DOT in predicting the prognosis of breast cancer. Results Microvessel density and total Hb were linearly correlated ( r = 0.584; P < .001). Total Hb and microvessel density were significantly increased in the metastasis group ( P = .001 and .027, respectively). A receiver operating characteristic curve analysis showed that at a total Hb cutoff value of 221.7 μmol/L, the sensitivity, specificity, and area under the curve of DOT for predicting recurrence or metastasis were 0.826, 0.516, and 0.660, respectively. Conclusions The total Hb concentration can reflect a tumor's blood supply. Patients with a high total Hb concentration and microvessel density have a higher risk for a poorer prognosis. Total Hb can be used as an indicator of breast cancer prognosis. Diffuse optical tomography can help physicians identify patients with a high risk of metastasis and make clinical decisions.