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Novel Contrast‐Enhanced Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Application and Future Directions
Author(s) -
Hwang Misun,
Jong Robert M.,
Herman Stephan,
Boss Renee,
Riggs Becky,
TekesBrady Aylin,
Spevak Melissa,
Poretti Andrea,
Soares Bruno P.,
Bailey Christopher R.,
Dunn Emily,
Shin Samuel S.,
Shrot Shai,
Huisman Thierry A.G.M.
Publication year - 2017
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14289
Subject(s) - medicine , microbubbles , perfusion , ultrasound , perfusion scanning , contrast enhanced ultrasound , contrast (vision) , radiology , ischemic injury , ischemia , cerebral perfusion pressure , cardiology , artificial intelligence , computer science
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast‐enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas‐filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast‐enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast‐enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.