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Sonographic Measurement of Cervical Volume in Pregnant Women at High Risk of Preterm Birth Using a Geometric Formula for a Frustum Versus 3‐Dimensional Automated Virtual Organ Computer‐Aided Analysis
Author(s) -
Ahmed Ahmed I.,
Aldhaheri Sarah R.,
RodriguezKovacs Javier,
Narasimhulu Deepa,
Putra Manesha,
Minkoff Howard,
Haberman Shoshana
Publication year - 2017
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14253
Subject(s) - medicine , frustum , confidence interval , volume (thermodynamics) , intraclass correlation , nuclear medicine , mathematics , geometry , clinical psychology , physics , quantum mechanics , psychometrics
Objectives To compare cervical volume measurements by 3‐dimensional (3D) sonography using Virtual Organ computer‐aided analysis (VOCAL; GE Healthcare, Milwaukee, WI) versus a manual method using a geometric formula for a frustum. Methods We included 142 asymptomatic pregnant women at 16 to 24 weeks gestation at high risk for preterm birth. With a Voluson 730 Expert system (GE Healthcare), they underwent 2‐dimensional (2D) transvaginal sonographic cervical length measurements and 3D cervical volume acquisition. The stored volumes were processed by VOCAL on a surface tablet. Cervical volume was manually calculated from the 2D images by using the formula V = 1/3 × π × h × ( r1 2 + r2 2 + r1 × r2 ), where V represents cervical volume; π was approximated as 3.14159; h , cervical length; r1 , radius at the internal os; and r2 , radius at the external os. Results Cervical volume was lower when obtained manually than by VOCAL, with a coefficient of variation of 30%, a mean difference of 10.1 ± 14.9 cm 3 ( P < .0001), and a poor interclass correlation coefficient of 0.62 (95% confidence interval [CI], 0.31 to 0.78). Both methods had good reproducibility; however, VOCAL had wider limits of agreement. A positive correlation was found between both methods ( r = 0.63; P < .0001). No correlation was found between cervical length by 2D transvaginal ultrasound and cervical volume by the VOCAL technique ( r = 0.06; 95% CI, −0.10 to 0.22) or cervical volume by the manual method ( r = 0.2; 95% CI, 0.08 to 0.39). Conclusions The cervix represents a frustum (truncated cone, r1 is not equal to r2) in shape rather than a cylinder. Both methods are reproducible; VOCAL is less reliable but provides higher values of cervical volume.