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Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5‐HTTLPR)
Author(s) -
Pieper Suzanne,
Out Dorothée,
BakermansKranenburg Marian J.,
van IJzendoorn Marinus H.
Publication year - 2011
Publication title -
journal of traumatic stress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.259
H-Index - 134
eISSN - 1573-6598
pISSN - 0894-9867
DOI - 10.1002/jts.20659
Subject(s) - serotonin transporter , genotype , 5 httlpr , dissociation (chemistry) , dissociative disorders , genetics , dissociative , allele , etiology , psychology , polymorphism (computer science) , clinical psychology , gene , medicine , biology , psychiatry , chemistry
We evaluated the role of the serotonin transporter gene promoter polymorphism (5‐HTTLPR) in the etiology of dissociation. Adult twin pairs ( N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5‐HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5‐HTTLPR reported more dissociative symptoms compared to participants with the other genotypes ( p = .02), and they showed more pathological dissociative symptoms than the other participants ( p = .04) when they reported more depressive symptoms and when they had experienced trauma.