Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5‐HTTLPR) | Zendy

Pieper Suzanne | Zendy; Out Dorothée | Zendy; BakermansKranenburg Marian J. | Zendy; van IJzendoorn Marinus H. | Zendy

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Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5‐HTTLPR)

Author(s) -

Pieper Suzanne,

Out Dorothée,

BakermansKranenburg Marian J.,

van IJzendoorn Marinus H.

Publication year - 2011

Publication title -

journal of traumatic stress

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.259

H-Index - 134

eISSN - 1573-6598

pISSN - 0894-9867

DOI - 10.1002/jts.20659

Subject(s) - serotonin transporter , genotype , 5 httlpr , dissociation (chemistry) , dissociative disorders , genetics , dissociative , allele , etiology , psychology , polymorphism (computer science) , clinical psychology , gene , medicine , biology , psychiatry , chemistry

We evaluated the role of the serotonin transporter gene promoter polymorphism (5‐HTTLPR) in the etiology of dissociation. Adult twin pairs ( N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5‐HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5‐HTTLPR reported more dissociative symptoms compared to participants with the other genotypes ( p = .02), and they showed more pathological dissociative symptoms than the other participants ( p = .04) when they reported more depressive symptoms and when they had experienced trauma.

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