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Selective recognition of tumor cells by molecularly imprinted polymers
Author(s) -
Fu Xiaopeng,
Li Yan,
Gao Shuang,
Lv Yongqin
Publication year - 2021
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202100137
Subject(s) - molecularly imprinted polymer , imprinting (psychology) , molecular imprinting , nanotechnology , genomic imprinting , polymer , chemistry , materials science , selectivity , biochemistry , gene , organic chemistry , gene expression , dna methylation , catalysis
Molecularly imprinted polymers, developed 50 years ago, have garnered enormous attention as receptor‐like materials. Lately, molecularly imprinted polymers have been employed as a specific target tool in favor of cancer diagnosis and therapy by the selective recognition of tumor cells. Although the molecular imprinting technology has been well‐innovated recently, the cell still remains the most challenging target for imprinting. In this review, we summarize the advances in the synthesis of molecularly imprinted polymers suitable for the selective recognition of tumor cells. Through a sustained effort, three strategies have been developed including peptide‐imprinting, polysaccharide‐imprinting, and whole‐cell imprinting, which have resulted in inspiring applications in effective cancer diagnosis and therapy. The major challenges and perspectives on the further directions related to the synthesis of molecularly imprinted polymers were also outlined.