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Application of HKUST‐1 metal‐organic framework as coating for headspace solid‐phase microextraction of some addictive drugs
Author(s) -
Baheri Tahmine,
Yamini Yadollah,
Shamsayei Maryam,
Tabibpour Mahmoud
Publication year - 2021
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202100070
Subject(s) - solid phase microextraction , chromatography , fiber , coating , analyte , detection limit , extraction (chemistry) , linear range , materials science , solid phase extraction , chemistry , analytical chemistry (journal) , gas chromatography–mass spectrometry , mass spectrometry , nanotechnology , composite material
In the present study, a copper‐based metal‐organic framework (HKUST‐1) was used first time for preconcentration trace amounts of addictive drugs in biological samples. HKUST‐1 was synthesized and coated onto the surface of stainless steel wire. The prepared coating was used in headspace solid‐phase microextraction method coupled with gas chromatography‐mass spectrometry for preconcentration and determination of some addictive drugs in biological fluids. Prepared coating shows good extraction efficiency due to large surface area, and π–π stacking interaction with selected analytes. Under optimum conditions, the method was validated with a reasonable determination coefficient ( R 2 > 0.9961) and suitable linear dynamic range (0.5–1000 μg L −1 ). Also, the limits of detections were obtained in the range of 0.1–0.4, 0.2–0.6, and 0.4–0.7 μg L −1 for water, urine, and plasma samples, respectively. The limits of quantification of present method were obtained in the range 0.5–1.3, 0.7–1.5, and 1.0–1.9 μg L −1 in water, urine, and plasma samples, respectively. The intra‐day and inter‐dye single fiber and fiber to fiber relative standard deviations were observed in the range 3.0–13.9% and 3.5–12.3%, respectively. Finally, the present method was applied for the determination of the drugs in biological samples.