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Front Cover: Analysis of the active components and metabolites of Taohong Siwu decoction by using ultra high performance liquid chromatography quadrupole time‐of‐flight mass spectrometry
Author(s) -
Duan Xianchun,
Pan Lingyu,
Peng Daiyin,
Bao Qiuyu,
Xiao Ling,
Zhou An,
Wu Huan,
Peng Can,
Chen Weidong
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202070211
Subject(s) - decoction , chromatography , chemistry , front cover , mass spectrometry , active ingredient , quadrupole time of flight , fragmentation (computing) , traditional medicine , pharmacology , tandem mass spectrometry , medicine , cover (algebra) , mechanical engineering , engineering , computer science , operating system
DOI: 10.1002/jssc.202000498 The cover picture shows Taohong Siwu Decoction (THSWD), a classic Chinese medicine prescription for treatment of the cerebral ischemia and gynecological diseases. UHPLC‐Q‐TOF‐MS was used to analyze the active components and metabolites of THSWD absorbed into the blood and the brain with the SD rat chosen as the research model. We identified 39 active compounds and 90 metabolites in the blood and brain by comparing retention times, accurate masses, fragmentation patterns, and literature data. M66, M90 and M73 were chosen as representatives to analyze the metabolism of the effective ingredients in THSWD in the body.