Premium
The separation and identification of synthetic cathinones by portable low microflow liquid chromatography with dual capillary columns in series and dual wavelength ultraviolet detection
Author(s) -
May Marisa C.,
Pavone David C.,
Lurie Ira S.
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202000767
Subject(s) - chromatography , analyte , repeatability , capillary electrochromatography , chemistry , capillary action , detection limit , analytical chemistry (journal) , capillary electrophoresis , materials science , composite material
This study ascertained the viability of a portable liquid chromatograph, operating at low microliter per minute flow, for the analysis of seized drugs at remote sites as well as in laboratory settings. Synthetic cathinones were screened using dual capillary columns in series, C8 and biphenyl, with on‐column ultraviolet detection at 255 and 275 nm. The relative retention times of the two columns in series and their peak area absorbance ratio were used to determine if the 16 synthetic cathinones investigated could be uniquely identified in these conditions. Based on these parameters all of the analytes could be distinguished. Representative mixtures of synthetic cathinones were used to determine the repeatability, linearity, and limits of detection of the method. This cost effective and green instrumentation has the potential to satisfy minimum international guidelines for the analysis of seized drugs.