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Liquid chromatographic separation of alkaloids in herbal medicines: Current status and perspectives
Author(s) -
Zhao WenJing,
Chen XuYan,
Liu YuQian,
Li Ping,
Li HuiJun
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202000081
Subject(s) - chromatographic separation , chromatography , resolution (logic) , druggability , chemistry , column (typography) , traditional medicine , high performance liquid chromatography , computer science , medicine , telecommunications , biochemistry , frame (networking) , artificial intelligence , gene
Abstract Alkaloids are a widespread group of basic compounds in herbal medicines and have attracted great interest due to various pharmaceutical activities and desirable druggability. Their distinctive structures make chromatographic separation fairly difficult. Peak tailing, poor resolution, and inferior column‐to‐column reproducibility are common obstacles to overcome. In order to provide a valuable reference, the methodologies and/or strategies on liquid chromatographic separation of alkaloids in herbal medicines proposed from 2012 to 2019 are thoroughly summarized.