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Preparing molecularly imprinted nanoparticles of saponins via cooperative imprinting strategy
Author(s) -
Zhang Hao,
Zhang Yanan,
Wang Hailing,
Wen Han,
Yan Zhifeng,
Huang Ailan,
Bie Zijun,
Chen Yang
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202000019
Subject(s) - imprinting (psychology) , molecular imprinting , chemistry , covalent bond , molecularly imprinted polymer , combinatorial chemistry , nanoparticle , amphiphile , hydrogen bond , selectivity , nanotechnology , organic chemistry , polymer , molecule , materials science , biochemistry , catalysis , copolymer , gene
Saponin is an important class of natural products with various pharmacological activities. The selective separation of saponins is an essential step before further analysis. Molecular imprinting has been an effective strategy for preparing antibody mimics. However, a facile and efficient imprinting strategy for saponins is still lacking owing to their amphiphilic nature. Herein, we have prepared the saponins imprinted nanoparticles via cooperative imprinting strategy. This new strategy relies on the combination of various non‐covalent interactions (hydrophobic and hydrogen bonding) and covalent boronate affinity interactions. The obtained imprinted nanoparticles could rebind specific saponins from complex matrices with good selectivity, superb tolerance to interference, and fast binding equilibrium. This method was verified to be versatile and facile. Thus, this strategy could greatly facilitate the preparation of imprinted nanoparticles for the specific recognition of saponins.