Premium
Inside Front Cover: Guidelines for tuning the macropore structure of monolithic columns for high‐performance liquid chromatography
Author(s) -
DoresSousa José Luís,
FernándezPumarega Alejandro,
Vos Jelle,
Lämmerhofer Michael,
Desmet Gert,
Eeltink Sebastiaan
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201970022
Subject(s) - macropore , porosity , materials science , monolithic hplc column , homogeneity (statistics) , polymer , high performance liquid chromatography , chromatography , chemistry , composite material , computer science , mesoporous material , biochemistry , machine learning , catalysis
DOI: 10.1002/jssc.201801092 The cover picture shows the typical interconnected macropore structure of polymer monolithic stationary phases and the separation power is highlighted by means of a state‐of‐the‐art peptide gradient separation. The ability to control the external porosity and to tune the dimensions of the macropore size on multiple length scales provides the possibility of tailoring the monolithic support structure towards separation performance. To realize unparalleled separation performance, highly ordered monolithic support structures with high external porosity need to be created, featuring globule sizes and macropore diameters in the 100–500 nm range. Realizing excellent structure homogeneity is a key aspect.