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Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis
Author(s) -
Foster Samuel W.,
Xie Xiaofeng,
Pham Michelle,
Peaden Paul A.,
Patil Leena M.,
Tolley Luke T.,
Farnsworth Paul B.,
Tolley H. Dennis,
Lee Milton L.,
Grinias James P.
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201901276
Subject(s) - chromatography , capillary action , fluidics , syringe driver , cartridge , syringe , chemistry , capillary electrophoresis , materials science , engineering , mechanical engineering , metallurgy , composite material , aerospace engineering
A newly developed portable capillary liquid chromatograph was investigated for the separation of various pharmaceutical and illicit drug compounds. The system consists of two high‐pressure syringe pumps capable of delivering capillary‐scale flow rates at pressures up to 10 000 psi. Capillary liquid chromatography columns packed with sub‐2 μm particles are housed in cartridges that can be inserted into the system and easily connected through high‐pressure fluidic contact points by simply applying a specific, predetermined torque rather than using standard fittings and less precise sealing protocols. Several over‐the‐counter analgesic drug separations are demonstrated, along with a simple online measurement of tablet dissolution. Twenty illicit drug compounds were also separated across six targeted drug panels. The results described in this study demonstrate the capability of this compact liquid chromatography instrument to address several important drug‐related applications while simplifying system operation, and greatly reducing solvent usage and waste generation essential for onsite analysis.