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Polyoxomolybdate 368 /polyaniline nanocomposite as a novel fiber for solid‐phase microextraction of antidepressant drugs in biological samples
Author(s) -
Amoli Hossein Salar,
Yamini Yadollah,
Darmani Hossein
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201901152
Subject(s) - solid phase microextraction , polyaniline , extraction (chemistry) , fiber , sorbent , materials science , nortriptyline , coating , adsorption , chromatography , composite number , detection limit , chemistry , chemical engineering , polymer , gas chromatography–mass spectrometry , nanotechnology , composite material , mass spectrometry , amitriptyline , organic chemistry , medicine , anesthesia , engineering , polymerization
A novel solid‐phase microextraction fiber was synthesized by coating a stainless steel wire with polyoxomolybdate 368 /polyaniline as a sorbent aimed at extraction of amitriptyline, nortriptyline, and doxepin as antidepressant drugs from urine and blood samples. The polyoxomolybdate 368 /polyaniline composite coating was applied using electropolymerization process under constant potential. This composition leads to enhanced extraction efficiency of the fiber. Scanning electron microscopy images show that huge three‐dimensional structures of polyoxomolybdate 368 in composite induced more non‐smooth and porous fiber. In order to optimize of the extraction process, a series of variables including concentration of the composite materials, coating thickness, pH, extraction time, salt addition, and stirring rate was investigated and optimum conditions were determined. Analysis of surface morphology and chemical composition was performed. High‐performance liquid chromatography was used for separation and evaluation of mentioned antidepressant drugs from the matrixes. The experiments indicated a detection limits of <0.2 ng/L and a linear dynamic range of 0.3–100 ng/L ( R 2 > 0.994). The relative recovery values were found to be in the range of 92–98%. It was concluded that the purposed fiber is highly efficient in analyzing traces of antidepressant drugs in urine and blood.