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Recent advances in breath analysis to track human health by new enrichment technologies
Author(s) -
Ghosh Chiranjit,
Singh Varoon,
Grandy Jonathan,
Pawliszyn Janusz
Publication year - 2020
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201900769
Subject(s) - breath gas analysis , complex matrix , computer science , sample preparation , sampling (signal processing) , chromatography , biochemical engineering , chemistry , engineering , filter (signal processing) , computer vision
Detection of biomarkers in exhaled breath has been gaining increasing attention as a tool for diagnosis of specific diseases. However, rapid and accurate quantification of biomarkers associated with specific diseases requires the use of analytical methods capable of fast sampling and preconcentration from breath matrix. In this regard, solid phase microextraction and needle trap technology are becoming increasingly popular in the field of breath analysis due to the unique benefits imparted by such methods, such as the integration of sampling, extraction, and preconcentration in a single step. This review discusses recent advances in breath analysis using these sample preparation techniques, providing a summary of recent developments of analytical methods based on breath volatile organic compounds analysis, including the successful identification of various biomarkers related to human diseases.