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Response surface methodology approach for the preparation of a molecularly imprinted polymer for solid‐phase extraction of fenoxycarb pesticide in mussels
Author(s) -
Atayat Amani,
Mergola Lucia,
Mzoughi Nadia,
Del Sole Roberta
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201900344
Subject(s) - molecularly imprinted polymer , solid phase extraction , detection limit , chromatography , mussel , extraction (chemistry) , sorbent , chemistry , carbamate , adsorption , freundlich equation , repeatability , selectivity , organic chemistry , ecology , biology , catalysis
The aim of this work was to develop an efficient method for the selective extraction and analysis of fenoxycarb, a carbamate pesticide, in mussel samples using a molecularly imprinted solid‐phase extraction device. The optimization of molecularly imprinted polymer synthesis was performed using the experimental design under the response surface methodology approach. A fast rebinding study and Freundlich isotherm adsorption were carried out to calculate binding capacity B , site number n , and affinity constant K f . The optimum molecularly imprinted polymer was successfully used as sorbent of a solid‐phase extraction cartridge for the determination of fenoxycarb in real mussel samples. The range of linearity was 0.3–30 mg/L with a correlation coefficient of 0.991. The limit of detection was 0.247 mg/kg. The recovery of fenoxycarb extracted from mussel samples of Mediterranean sea was 97% ( n = 3) with relative standard deviation between 6 and 7% proving the reliability of the developed method.