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Simultaneous determination of 17 bisphenols in polycarbonate by ultra‐high performance supercritical fluid chromatography with tandem mass spectrometry
Author(s) -
Zhang Yujia,
Ling Yun,
Zhang Yuan,
Yao Guihong,
Yao Meiyi,
Zhang Feng
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201900279
Subject(s) - chromatography , chemistry , detection limit , polycarbonate , ammonium hydroxide , supercritical fluid chromatography , mass spectrometry , calibration curve , tandem mass spectrometry , methanol , supercritical fluid , analytical chemistry (journal) , high performance liquid chromatography , organic chemistry
A novel method was developed for the first time for the determination of 17 bisphenols by ultra‐high performance supercritical fluid chromatography with tandem mass spectrometry. Under the optimal conditions, 17 bisphenols were separated successfully on a high density diol column in 9 min using methanol and carbon dioxide as mobile phase. 0.02% ammonium hydroxide/methanol v/v was used as the post‐column compensation solvent to improve response of mass spectrometry. Linear relations of matrix‐matched calibration curve were favorable over the selected concentration range of 1–100 μg/kg with correlation coefficients greater than 0.9981. The method limit of detection and limit of quantitation were 0.1–0.5 μg/kg and 0.5–2.5 μg/kg, respectively. The average recoveries at three spiked levels in polycarbonate were in the range of 81.8–114.5%. Intra‐day and inter‐day precisions for six replicates were below 15.0%. This method was successfully applied to determine bisphenols in polycarbonate.