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An insight into chiral monolithic stationary phases for enantioselective high‐performance liquid chromatography applications
Author(s) -
Fouad Ali,
Ibrahim Diana,
Adly Frady G.,
Ghanem Ashraf
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201900159
Subject(s) - chiral stationary phase , enantioselective synthesis , high performance liquid chromatography , stationary phase , coating , capillary action , materials science , surface modification , chromatography , polymer , capillary electrochromatography , nanotechnology , chemistry , organic chemistry , catalysis , composite material
In this review, three main classes of chiral monolithic stationary phases, namely silica‐, organic polymer‐, and hybrid‐based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional‐packed and open‐tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.