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Evaluating novel silica hydride‐based stationary phases for the analysis of phytocannabinoids and other psychoactive drugs
Author(s) -
Watanabe Seiichiro,
Santos Theresa Q.,
MatyskaPesek Maria T.,
Pesek Joseph J.
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201900013
Subject(s) - cannabidiol , chemistry , chromatography , bioanalysis , mass spectrometry , delta 9 tetrahydrocannabinol , matrix (chemical analysis) , cannabis , cannabinoid , psychology , biochemistry , receptor , psychiatry
Three silica hydride based novel chromatographic phases chemically‐bonded with allyloxy‐DL‐alpha‐tocopherol, allylpentafluorophenyl, and 1‐eicosene moieties were evaluated as separation media for selected phytocannabinoids and other substances of abuse. In order to assess column selectivity, a series of reference standards was analyzed and detected by using liquid chromatography with mass spectrometry. Further, quantitative detections of cannabidiol and tetrahydrocannabinol were attempted for the extracts of cannabis plants and cannabidiol gummy formulation. For potential bioanalytical applications, the columns were evaluated for substance screening in a human urine matrix. In summary, the newly developed columns are functional and effective for the analysis of phytocannabinoids and various psychoactive drugs with or without the presence of biological matrices.