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Electrospun metal‐organic framework/polyacrylonitrile composite nanofibrous mat as a microsorbent for the extraction of tetracycline residue in human blood plasma
Author(s) -
Arabsorkhi Batoul,
Sereshti Hassan,
Abbasi Alireza
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201801305
Subject(s) - polyacrylonitrile , electrospinning , fourier transform infrared spectroscopy , extraction (chemistry) , scanning electron microscope , adsorption , solid phase extraction , nanofiber , materials science , solid phase microextraction , chromatography , chemistry , analytical chemistry (journal) , desorption , detection limit , tetracycline antibiotics , tetracycline , nuclear chemistry , mass spectrometry , chemical engineering , nanotechnology , gas chromatography–mass spectrometry , composite material , organic chemistry , polymer , biochemistry , antibiotics , engineering
A new composite nanofiber of polyacrylonitrile doped with copper benzene‐1,3,5‐tricarboxylate metal‐organic framework was fabricated by electrospinning and used as a microsorbent in the solid‐phase extraction of trace tetracycline. The chemical structure of the adsorbent was studied by X‐ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller surface area analysis, and Barrett‐Joyner‐Halenda pore size and volume analysis techniques. The significant parameters of the method including desorption solvent kind and volume, adsorbent mass, pH, and salt percentage were investigated. At the optimized conditions, the linear range was 8–1000 μg/L with a determination coefficient ( R 2 ) of 0.9954. The limits of detection and quantification were 2.40 and 8.00 μg/L, respectively. The inter‐ and intraday precisions were 4.7 and 3.4%, respectively. The developed extraction method was followed by high‐performance liquid chromatography and applied for the determination of tetracycline in human blood plasma, and good relative recoveries (97.3‐104.5%) were obtained.