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Resistive pulse sensing as particle counting and sizing method in microfluidic systems: Designs and applications review
Author(s) -
Vaclavek Tomas,
Prikryl Jan,
Foret Frantisek
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201800978
Subject(s) - microfluidics , bioanalysis , nanotechnology , resistive touchscreen , microfabrication , sizing , digital microfluidics , computer science , materials science , chemistry , optoelectronics , electrowetting , fabrication , medicine , alternative medicine , organic chemistry , pathology , computer vision , dielectric
Resistive pulse sensing is a well‐known and established method for counting and sizing particles in ionic solutions. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications, which were hardly possible before microfabrication gained the present broad adoption. In this review, we provide a comprehensive overview of microfluidic designs along with electrode arrangements with emphasis on applications focusing on bioanalysis and analysis of single cells that were reported within the past five years.