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Capillary electrophoresis for the analysis of antidepressant drugs: A review
Author(s) -
Abdul Keyon Aemi Syazwani,
Miskam Mazidatulakmam,
Ishak Nur Syazwani,
Mahat Naji Arafat,
Mohamed Huri Mohamad Afiq,
Abdul Wahab Roswanira,
Chandren Sheela,
Abdul Razak Fazira Ilyana,
Ng NyukTing,
Ali Timothy Gandu
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201800859
Subject(s) - capillary electrophoresis , micellar electrokinetic chromatography , antidepressant , chromatography , chemistry , tricyclic antidepressant , pharmacology , medicine , psychiatry , anxiety
Depression is a common mental disorder that may lead to major mental health problems, and antidepressant drugs have been used as a treatment of choice to mitigate symptoms of major depressive disorders by ameliorating the chemical imbalances of neurotransmitters in brain. Since abusing antidepressant drugs such as selective serotonin reuptake inhibitors and tricyclic antidepressant drugs can cause severe adverse effects, continuous toxicological monitoring of the parent compounds as well as their metabolites using numerous analytical methods appears pertinent. Among them, capillary electrophoresis has been popularly utilized since the method has a lot of advantages viz . using small amounts of sample and solvents, ease of operation, and rapid analysis. This review paper brings a survey of more than 30 papers on capillary electrophoresis of antidepressant drugs published approximately from 1999 until 2018. It focuses on the reported capillary electrophoresis techniques and their applications and challenges for determining antidepressant drugs and their metabolites. It is organized according to the commonly used capillary zone electrophoresis method, followed by non‐aqueous capillary electrophoresis and micellar electrokinetic chromatography, with details on breakthrough findings. Where available, information is given about the background electrolyte used, detector utilized, and sensitivity obtained.