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Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin
Author(s) -
Li Yanan,
Chen Hong,
Zhu Yu,
Zhang Tingting,
Gu Jiali,
Xu Yongxia,
Li Jianrong
Publication year - 2018
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201800649
Subject(s) - ciprofloxacin , malachite green , chemistry , chromatography , adsorption , antibacterial agent , in situ , ciprofloxacin hydrochloride , polymer , molecularly imprinted polymer , norfloxacin , ionic strength , ionic bonding , analytical chemistry (journal) , selectivity , ion , antibiotics , organic chemistry , biochemistry , aqueous solution , catalysis
A technique of diffusive gradients in thin films with ciprofloxacin‐molecularly imprinted polymers as the binding agent was developed for in situ selective sampling and measurement of ciprofloxacin in water. The ciprofloxacin uptake by the method increased linearly with time ( r 2 = 0.998) with a recovery of 96.8% in synthetic solution. The method performance was not dependent on solution pH over the pH range of 2–11 and ionic strength range from 1 × 10 −4 to 0.5 mol/L sodium nitrate. The binding agent has a higher adsorption affinity for ciprofloxacin than for other drug residues, such as norfloxacin, chloramphenicol, and malachite green. The concentration of ciprofloxacin in river water determined by this method was 0.52 ± 0.3 μg/L, and the recoveries of ciprofloxacin were 96.1–102.0%.