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Recent advances in the preparation of adsorbent layers for thin‐layer chromatography combined with matrix‐assisted laser desorption/ionization mass‐spectrometric detection
Author(s) -
Kucherenko Elizaveta,
Kanateva Anastasiia,
Pirogov Andrey,
Kurganov Alexander
Publication year - 2019
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201800625
Subject(s) - mass spectrometry , chromatography , chemistry , desorption , analyte , analytical chemistry (journal) , adsorption , sample preparation , matrix (chemical analysis) , thin layers , matrix assisted laser desorption/ionization , surface enhanced laser desorption/ionization , sample preparation in mass spectrometry , materials science , electrospray ionization , organic chemistry , composite material
This review is focused on planar chromatography hyphenated with mass‐spectrometric detection for analysis of low‐molecular‐mass solutes. Various kinds of hyphenations are discussed with attention paid to the preparation of thin layer plates suited both for the mass‐spectrometric detection of the resolved solutes direct from thin‐layer plates and for indirect mass‐spectrometric detection of the resolved solutes, performed by scraping, extracting, purifying, and concentrating the analyte from the thin‐layer chromatography plate. Plates with monolithic layers are relatively new for thin‐layer chromatography but they can successfully be combined with mass‐spectrometric technique in a pursuit of comprehensive local sample composition information. Preparation of monolithic layers of different porosity and structure based on organic, inorganic, and composite materials is illustrated together with examples of successful separation and detection of low‐molecular‐mass solutes by means of matrix‐assisted and surface‐assisted laser desorption mass spectrometry.