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Solid‐phase extraction of drugs with cuttlefish bone powder as a sorbent
Author(s) -
Khazri Hassen,
GhorbelAbid Ibtissem,
Debrauwer Laurent,
Kalfat Rafik,
TrabelsiAyadi Malika
Publication year - 2018
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201800419
Subject(s) - sorbent , extraction (chemistry) , chromatography , naproxen , ibuprofen , solid phase extraction , chemistry , cuttlefish , matrix (chemical analysis) , phase (matter) , adsorption , pharmacology , organic chemistry , medicine , alternative medicine , food science , pathology
We investigated cuttlefish bone powder for the solid‐phase extraction of naproxen, ibuprofen, and carbamazepine. The basic principles controlling the extraction are presented to aid in the choice of the nature and quantity of the extracting phase according to the sample matrix and the solute properties, based on the mechanisms of phase retention. Their retention mechanism is based on hydrogen bonding and electrostatic interactions. The results show a significant recovery rate for the three drugs, selectivity, and low cost. The method has successfully reduced the amount of tested pharmaceuticals with recoveries >87% at pH 4.