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Application of liquid–liquid microextraction for the effective separation and simultaneous determination of 11 pharmaceuticals in wastewater samples using high‐performance liquid chromatography with tandem mass spectrometry
Author(s) -
Diuzheva Alina,
Balogh József,
Jekő József,
Cziáky Zoltán
Publication year - 2018
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201800309
Subject(s) - chromatography , chemistry , mass spectrometry , extraction (chemistry) , detection limit , liquid chromatography–mass spectrometry , liquid–liquid extraction , high performance liquid chromatography , wastewater , liquid liquid , tandem mass spectrometry , sample preparation , engineering , waste management
Abstract A dispersive liquid–liquid microextraction method for the simultaneous determination of 11 pharmaceuticals has been developed. The method is based on a microextraction procedure applied to wastewater samples from different regions of Hungary followed by high‐performance liquid chromatography with mass spectrometry. The effect of the nature of the extractant, dispersive solvent, different additives, and extraction time were examined on the extraction efficiently of the dispersive liquid–liquid microextraction method. Under optimal conditions, the linearity for determining the pharmaceuticals was in the range of 1–500 ng/mL, with the correlation coefficients ranging from 0.9922 to 0.9995. The limits of detection and limits of quantification were in the range of 0.31–6.65 and 0.93–22.18 ng/mL, respectively.