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Back Cover: A sensitive UHPLC–MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study
Author(s) -
Kim SookJin,
Shin Hwajin,
Cheon SeongMoon,
Ko Semi,
Ham SeongHo,
Kwon YoungDal,
Lee YongBok,
Cho HeaYoung
Publication year - 2017
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201770172
Subject(s) - human plasma , chromatography , pharmacokinetics , lignan , chemistry , calibration curve , calibration , detection limit , pharmacology , stereochemistry , mathematics , medicine , statistics
J. Sep. Sci . 2017, 40 , 3430–3439 DOI: 10.1002/jssc.201700588 The back cover picture shows a development and validation of UPLC‐MS/MS method of three lignans, schizandrin, schizandrol B, and gomisin N in biological samples. The chromatograms represent the simultaneously determined three lignans in human plasma with the calibration curve range of 0.05–50 ng/ml. A quantification method was successfully applied to evaluation of the pharmacokinetics for three lignans after administration of Schizandrae Fructus extract powder to humans.