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Simultaneous derivatization and lighter‐than‐water air‐assisted liquid–liquid microextraction using a homemade device for the extraction and preconcentration of some parabens in different samples
Author(s) -
Farajzadeh Mir Ali,
Bakhshizadeh Aghdam Mehri,
Afshar Mogaddam Mohammad Reza,
Alizadeh Nabil Ali Akbar
Publication year - 2018
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201701022
Subject(s) - chromatography , derivatization , detection limit , extraction (chemistry) , solvent , chemistry , analyte , sample preparation , xylene , liquid–liquid extraction , high performance liquid chromatography , toluene , organic chemistry
Simultaneous derivatization and air‐assisted liquid–liquid microextraction using an organic that is solvent lighter than water has been developed for the extraction of some parabens in different samples with the aid of a newly designed device for collecting the extractant. For this purpose, the sample solution is transferred into a glass test tube and a few microliters of acetic anhydride (as a derivatization agent) and p ‐xylene (as an extraction solvent) are added to the solution. After performing the procedure, the homemade device consists of an inverse funnel with a capillary tube placed into the tube. In this step, the collected extraction solvent and a part of the aqueous solution are transferred into the device and the organic phase indwells in the capillary tube of the device. Under the optimal conditions, limits of detection and quantification for the analytes were obtained in the ranges of 0.90–2.7 and 3.0–6.1 ng/mL, respectively. The enrichment and enhancement factors were in the ranges of 370–430 and 489–660, respectively. The method precision, expressed as the relative standard deviation, was within the range of 4–6% ( n = 6) and 4–9% ( n = 4) for intra‐ and interday precisions, respectively. The proposed method was successfully used for the determination of methyl‐, ethyl‐, and propyl parabens in cosmetic, hygiene and food samples, and personal care products.