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Cryogenic modulation fast GC × GC–MS using a 10 m microbore column combination: Concept, method optimization, and application
Author(s) -
Giocastro Barbara,
Piparo Marco,
Tranchida Peter Q.,
Mondello Luigi
Publication year - 2018
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201700824
Subject(s) - two dimensional gas , two dimensional chromatography , analytical chemistry (journal) , modulation (music) , chemistry , chromatography , dimension (graph theory) , resolution (logic) , gas chromatography , mass spectrometry , column (typography) , sample preparation , mathematics , computer science , physics , connection (principal bundle) , artificial intelligence , geometry , acoustics , pure mathematics
The present research is based on the concept of using a 10 m × 0.1 mm id column for cryogenic‐modulation fast comprehensive two‐dimensional gas chromatography with quadrupole mass spectrometry. Specifically, an 8.9 m × 0.1 mm id low‐polarity column was used as the first dimension, and a 1.1 m × 0.1 mm id medium‐polarity column was used as the second dimension. The main scope of the investigation was to develop a high peak‐capacity method, with an analysis time of approximately 10 min. Various aspects related to method optimization are discussed, as well as separation parameters such as peak capacity (in each dimension, and as a total value), first‐dimension sample capacity, peak widths, modulation ratio, sensitivity enhancement, and number of spectra per peak. The fast approach was evaluated in applications involving a mixture of cosmetic allergens and a sample of perfume. The approach proposed enables high‐resolution separations in a short time (across the C 8 –C 23 alkane range), as well as a considerable reduction of the consumption of gases for modulation cooling and heating.