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Development of a high‐throughput method based on thin‐film microextraction using a 96‐well plate system with a cork coating for the extraction of emerging contaminants in river water samples
Author(s) -
Morés Lucas,
Dias Adriaeves,
Carasek Eduardo
Publication year - 2018
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201700774
Subject(s) - detection limit , chromatography , solid phase microextraction , extraction (chemistry) , chemistry , triclocarban , sample preparation , analytical chemistry (journal) , gas chromatography–mass spectrometry , mass spectrometry , medicine , pathology , triclosan
Abstract In this study, a new method was developed in which a biosorbent material is used as the extractor phase in conjunction with a recently described sample preparation technique called thin‐film microextraction and a 96‐well plate system. The method was applied for the determination of emerging contaminants, such as 3‐(4‐methylbenzylidene) camphor, ethylparaben, triclocarban, and bisphenol A in water samples. The separation and detection of the analytes were performed by high‐performance liquid chromatography with diode array detection. These contaminants are considered hazardous to human health and other living beings. Thus, the development of an analytical method to determine these compounds is of great interest. The extraction parameters were evaluated using multivariate and univariate optimization techniques. The optimum conditions for the method were 3 h of extraction time, 20 min of desorption with 300 μL of acetonitrile and methanol (50:50, v/v), and the addition of 5% w/v sodium chloride to the sample. The analytical figures of merit showed good results with linear correlation coefficients higher than 0.99, relative recoveries of 72–125%, interday precision ( n = 3) of 4–18%, and intraday precision ( n = 9) of 1–21%. The limit of detection was 0.3–5.5 μg/L, and the limit of quantification was 0.8–15 μg/L.