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Development and evaluation of microwave‐assisted and ultrasound‐assisted methods based on a quick, easy, cheap, effective, rugged, and safe sample preparation approach for the determination of bisphenol analogues in serum and sediments
Author(s) -
Song Shanjun,
Shao Mingwu,
Wang Weihua,
He Yajuan,
Dai Xinhua,
Wang Huiyu,
Liu Liliang,
Guo Feng
Publication year - 2017
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201700628
Subject(s) - chromatography , extraction (chemistry) , chemistry , amine gas treating , bisphenol a , sample preparation , tetrahydrofuran , methanol , solvent , organic chemistry , epoxy
Abstract Microwave‐ and ultrasound‐assisted methods based on a quick, easy, cheap, effective, rugged, and safe sample preparation approach followed by high‐performance liquid chromatography with tandem mass spectrometry were developed for the simultaneous determination of eight bisphenol analogues in serum and sediment. The developed methods provided satisfactory extraction efficiency for the energy provided by microwaves and ultrasound. Compositions of commercial sorbents (primary secondary amine, MgSO 4 , octadecyl‐modified silica, and graphitized carbon black) were evaluated. The ultrasound‐assisted method was suited for serum using primary secondary amine, MgSO 4 , and octadecyl‐modified silica as sorbents and a mixture of hexane and ethyl acetate as extraction solvent. The microwave‐assisted method worked better for sediment with tetrahydrofuran and methanol as solvents and primary secondary amine, MgSO 4 , octadecyl‐modified silica, and graphitized carbon black as sorbents. Other experimental parameters, such as extraction temperature and time, were also optimized. The inter‐ and intraday relative standard deviations ranged from 2.7 to 5.5%. The limits of detection were between 0.1 and 1.0 ng/mL for serum and between 0.1 and 0.5 ng/g dry weight for sediment. The proposed methods were successfully applied to seven sediment and 20 human serum samples. The results showed that the developed methods were practical for the analysis and biomonitoring of bisphenols in sera and sediment.