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Chiral separation of quinolones by liquid chromatography and capillary electrophoresis
Author(s) -
Ali Imran,
Suhail Mohd.,
Asnin Leonid
Publication year - 2017
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201700200
Subject(s) - capillary electrophoresis , enantiomer , enantioselective synthesis , context (archaeology) , chromatography , chemistry , quinolone , combinatorial chemistry , cyclodextrin , organic chemistry , antibiotics , biochemistry , paleontology , biology , catalysis
The quinolones are derivatives of oxoquinolines and mostly known for their antibacterial and antiviral activities. Many quinolones are chiral compounds having asymmetric centers and important due to their enantioselective biological activities. In order to study the biological activities of quinolone enantiomers, to control the manufacturing of homochiral drugs and to prepare necessary quantities of pure enantiomers for preclinical or clinical trials, respective chiral separation methods are urgently needed. In this context, the present review discusses chromatographic and electrophoretic methods for the enantioseparation of chiral quinolones and provides some useful information on their physical and pharmaceutical properties. The drawbacks of currently used techniques are revealed and ways to overcome them are outlined. Moreover, recommendations for an optimal choice of a separation protocol are given.