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Comprehensive study of the macropore and mesopore size distributions in polymer monoliths using complementary physical characterization techniques and liquid chromatography
Author(s) -
Wouters Sam,
Hauffman Tom,
MittelmeijerHazeleger Marjo C.,
Rothenberg Gadi,
Desmet Gert,
Baron Gino V.,
Eeltink Sebastiaan
Publication year - 2016
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201670231
Subject(s) - macropore , polymer , mesoporous material , copolymer , characterization (materials science) , homogeneity (statistics) , monolithic hplc column , materials science , microscale chemistry , dispersion (optics) , chemical engineering , chromatography , chemistry , chemical physics , high performance liquid chromatography , nanotechnology , composite material , organic chemistry , optics , catalysis , statistics , mathematics , mathematics education , physics , engineering
J. Sep. Sci . 2016, 39 , 4492–4501 DOI: 10.1002/jssc.201600896 Organic polymer‐based monolithic stationary phases with a large and small domain size were synthesized via free‐radical copolymerization. The resulting pore structures were characterized at the meso‐ and macroscopic levels. In addition, nanoLC experiments were conducted to establish a fundamental understanding between column structure and kinetic performance. The structural homogeneity of the small‐domain size monoliths was compromised by the presence of a small number of large macropores, which induced a significant eddy‐dispersion contribution to band broadening.
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