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Spiral counter‐current chromatography: Design, development, application, and challenges
Author(s) -
Huang XinYi,
Sun XiaoMing,
Pei Dong,
Di DuoLong
Publication year - 2017
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201600927
Subject(s) - countercurrent chromatography , chromatography , current (fluid) , spiral (railway) , chemistry , materials science , column chromatography , process engineering , engineering , electrical engineering , mechanical engineering
Depending on the rapid growth in the radial gradient of the centrifugal force, spiral counter‐current chromatography can greatly improve the retention of stationary phase, especially for the aqueous two‐phase systems with ultra‐polar and high viscosity that are not well retained in the conventional multilayer coils counter‐current chromatography. As a result, it is an attractive and alternative technology that is suited for separation of hydrophilic compounds and has led to many exciting progress in recent years. This review presents the recent advances and applications of spiral counter‐current chromatography, including its major benefits and limitations, some novel methods to improve the separation efficiency and its applications in separation of real samples. In addition, the remaining challenges and future perspectives on development of spiral counter‐current chromatography also are proposed in this article.