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Rapid and efficient enantioseparation of ( S )‐amlodipine by surface‐imprinted core–shell polymer microspheres
Author(s) -
Lai Shenzhi,
Chen Chunyan,
Ouyang Xiaoli,
Qin Yanru,
Cai Changqun,
Chen Xiaoming
Publication year - 2016
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201600850
Subject(s) - molecularly imprinted polymer , polymer , amlodipine , mesoporous material , polymerization , adsorption , chemical engineering , precipitation polymerization , cationic polymerization , chromatography , pulmonary surfactant , chemistry , mesoporous silica , molecular imprinting , materials science , polymer chemistry , selectivity , organic chemistry , radical polymerization , catalysis , medicine , blood pressure , engineering , radiology
We present a protocol for the preparation of surface‐imprinted polymer microspheres by core–shell precipitation polymerization for the enantioseparation of ( S )‐amlodipine. In this work, submicron mesoporous silica microspheres were prepared with gemini cationic surfactant as soft template. Molecularly imprinted polymers were coated on the silica supports with a low level of crosslinking, and the thickness of the thin‐walled imprinted shell was about 45 nm. The material showed fast binding kinetics for ( S )‐amlodipine (within only 20 min for complete equilibrium), and the saturation adsorption capacity reached 309.2 mg/g, indicating the good accessibility of binding sites and improved mass transfer for target molecule. The imprinted microspheres exhibited an appreciable enantiomeric excess of ( S )‐amlodipine of 11.3% when used as a glass chromatography column for the enantioseparation of ( S )‐amlodipine from amlodipine besylate without extra chiral additives. The surface‐imprinted materials display potentially amplification for industrial enantioseparation of ( S )‐amlodipine.