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Inverse colloidal crystal membranes for hydrophobic interaction membrane chromatography
Author(s) -
Vu Anh T.,
Wang Xinying,
Wickramasinghe S. Ranil,
Yu Bing,
Yuan Hua,
Cong Hailin,
Luo Yongli,
Tang Jianguo
Publication year - 2015
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201570161
Subject(s) - membrane , polyvinylidene fluoride , methacrylate , chemistry , colloidal crystal , chromatography , copolymer , colloid , porosity , synthetic membrane , chemical engineering , materials science , polymer chemistry , polymer , organic chemistry , biochemistry , engineering
J. Sep. Sci. 2015, 38, 2819–2825 DOI: 10.1002/jssc.201500295 Cover picture illustrates a novel procedure for the preparation of inverse colloidal crystal (ICC) membranes of polyhydroxybutyl methacrylate based copolymers using silica colloidal crystals as templates. The ICC membranes have uniform pores, high porosity and therefore surface area for protein binding, are used as hydrophobic interaction membrane chromatography membranes for humanized monoclonal antibody immunoglobulin G purification. The capacity of the ICC membranes is up to 10 times greater than commercially available polyvinylidene fluoride membranes with a similar pore size.