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Enantioselective separation and pharmacokinetic dissipation of cyflumetofen in field soil by ultra‐performance convergence chromatography with tandem mass spectrometry
Author(s) -
Liu Na,
Dong Fengshou,
Xu Jun,
Liu Xingang,
Chen Zenglong,
Pan Xinglu,
Chen Xixi,
Zheng Yongquan
Publication year - 2016
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201501123
Subject(s) - enantioselective synthesis , chemistry , chromatography , enantiomer , tandem mass spectrometry , mass spectrometry , triple quadrupole mass spectrometer , tandem , selected reaction monitoring , organic chemistry , materials science , catalysis , composite material
Little data on the enantioselective separation of cyflumetofen exists, despite the fact that such data are essential to the assessment of the fate and potential toxic effects of cyflumetofen enantiomers. To address this issue, a simple and sensitive method for the enantioselective determination of cyflumetofen enantiomers in soil has been established using ultra performance convergence chromatography tandem triple quadrupole mass spectrometry. The effects of the chiral stationary phases, mobile phase, auto backpressure regulator pressure, column temperature, flow rate of the mobile phase, and compensation pump solvent were evaluated. The proposed method was applied to the study of the pharmacokinetic dissipation of cyflumetofen stereoisomers in soil under greenhouse conditions. The estimated half‐life of cyflumetofen isomers ranged from 12.2 to 13.6 days, and statistically significant enantioselective degradation was observed. This study not only demonstrates that there is an efficient and sensitive method for cyflumetofen enantioseparation, but also provides the first experimental evidence of the pharmacokinetic dissipation of cyflumetofen stereoisomers in the environment.