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Analyses of acute kidney injury biomarkers by ultra‐high performance liquid chromatography with mass spectrometry
Author(s) -
Za'abi Mohammed Al,
Ali Badreldin H.,
ALOthman Zeid A.,
Ali Imran
Publication year - 2016
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.201500982
Subject(s) - acute kidney injury , chromatography , mass spectrometry , urine , high performance liquid chromatography , kidney , medicine , chemistry
The newly developed acute kidney injury biomarkers are very important for the early and timely detection of kidney diseases. This review contains details of the analyses of several acute kidney injury biomarkers using ultra‐high performance liquid chromatography‐mass spectrometry in urine and plasma samples. In this review we attempt to discuss some aspects of the types of the biomarkers, patents, sample preparation, and the analyses. Besides, efforts were also made to discuss the possible uses of superficially porous (core–shell) columns in traditional and inexpensive high‐performance liquid chromatography instruments. Additionally, the challenges and the future prospects are also highlighted. The present review will be useful for the academicians, scientists, and clinicians for the early detection of acute kidney injury biomarkers.